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4 March 2022 The functions of Wt1 in mouse gonad development and somatic cells differentiation
Min Chen, Changhuo Cen, Nan Wang, Zhiming Shen, Mengyue Wang, Bowen Liu, Jiayi Li, Xiuhong Cui, Yanbo Wang, Fei Gao
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Abstract

Wilms' tumor 1 (Wt1) encodes a zinc finger nuclear transcription factor which is mutated in 15–20% of Wilms' tumor, a pediatric kidney tumor. Wt1 has been found to be involved in the development of many organs. In gonads, Wt1 is expressed in genital ridge somatic cells before sex determination, and its expression is maintained in Sertoli cells and granulosa cells after sex determination. It has been demonstrated that Wt1 is required for the survival of the genital ridge cells. Homozygous mutation of Wt1 causes gonad agenesis. Recent studies find that Wt1 plays important roles in lineage specification and maintenance of gonad somatic cells. In this review, we will summarize the recent research works about Wt1 in gonadal somatic cell differentiation.

Summary Sentence

Wt1 is indispensable for somatic cell differentiation and gonad development at different developmental stages.

© The Author(s) 2022. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Min Chen, Changhuo Cen, Nan Wang, Zhiming Shen, Mengyue Wang, Bowen Liu, Jiayi Li, Xiuhong Cui, Yanbo Wang, and Fei Gao "The functions of Wt1 in mouse gonad development and somatic cells differentiation," Biology of Reproduction 107(1), 269-274, (4 March 2022). https://doi.org/10.1093/biolre/ioac050
Received: 7 December 2021; Accepted: 24 February 2022; Published: 4 March 2022
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KEYWORDS
granulosa cells
Sertoli cells
Wt1
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