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21 March 2022 Environmental epigenetic interaction of gametes and early embryos
Xin-Yuan Li, Jie-Xue Pan, Hong Zhu, Guo-Lian Ding, He-Feng Huang
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In recent years, the developmental origins of diseases have been increasingly recognized and accepted. As such, it has been suggested that most adulthood chronic diseases such as diabetes, obesity, cardiovascular disease, and even tumors may develop at a very early stage. In addition to intrauterine environmental exposure, germ cells carry an important inheritance role as the primary link between the two generations. Adverse external influences during differentiation and development can cause damage to germ cells, which may then increase the risk of chronic disease development later in life. Here, we further elucidate and clarify the concept of gamete and embryo origins of adult diseases by focusing on the environmental insults on germ cells, from differentiation to maturation and fertilization.

© The Author(s) 2022. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail:
Xin-Yuan Li, Jie-Xue Pan, Hong Zhu, Guo-Lian Ding, and He-Feng Huang "Environmental epigenetic interaction of gametes and early embryos," Biology of Reproduction 107(1), 196-204, (21 March 2022).
Received: 30 December 2021; Accepted: 24 February 2022; Published: 21 March 2022
Epigenetic inheritance
intergenerational/transgenerational transmission
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