Translator Disclaimer
2 April 2022 Recent progress of proteomic analysis on spermatogenesis
Haotian Zhang, Chenghao Situ, Xuejiang Guo
Author Affiliations +
Abstract

Testis, the only organ responsible for generating sperm, is by far the organ with the largest variety of proteins and tissue-specific proteins in humans. In testis, spermatogenesis is a multi-step complex process well-accepted that protein and mRNA are decoupled in certain stages of spermatogenesis. With the fast development of mass spectrometry-based proteomics, it is possible to systemically study protein abundances and modifications in testis and sperm to help us understand the molecular mechanisms of spermatogenesis. This review provides an overview of the recent progress of proteomics analysis on spermatogenesis, including protein expression and multiple post-translational modifications, such as phosphorylation, glycosylation, ubiquitylation, and acetylation.

Summary Sentence

Proteomic analysis of protein expression and multiple post-translational modifications (PTMs), including phosphorylation, ubiquitylation, acetylation, and glycosylation, showed complex protein regulations in spermatogenesis and male infertility and identified biomarkers for male infertility.

© The Author(s) 2022. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Haotian Zhang, Chenghao Situ, and Xuejiang Guo "Recent progress of proteomic analysis on spermatogenesis," Biology of Reproduction 107(1), 109-117, (2 April 2022). https://doi.org/10.1093/biolre/ioac065
Received: 31 December 2021; Accepted: 22 March 2022; Published: 2 April 2022
JOURNAL ARTICLE
9 PAGES


Share
SHARE
KEYWORDS
Male infertility
post-translational modifications
proteomics
sperm
spermatogenesis
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top