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27 April 2022 Potential clinical value of in vitro spermatogenesis
Laihua Li, Yan Yuan, Jiahao Sha
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Abstract

Infertility has become the third most common disease threatening human health, immediately after tumors and cardiovascular diseases. Male infertility is primarily caused by spermatogenesis disorders that may be classified as either genetic or non-genetic. For part of non-genetic disorders, in vitro spermatogenesis can be induced by adjusting the microenvironment of the testis culture. Establishing the in vitro spermatogenic induction system helps to clarify the critical molecular mechanisms in spermatogonia self-renewal, spermatocyte meiosis, and sperm formation during spermatogenesis. In this review, we summarize recent advances in the field of in vitro sperm cells induction. Therefore, we hope to provide ideas and solutions for the clinical treatment of male infertility.

Summary Sentence This review provides recent advances in the field of in vitro sperm cells induction and discusses potential clinical value of in vitro spermatogenesis.

Graphical Abstract

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© The Author(s) 2022. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Laihua Li, Yan Yuan, and Jiahao Sha "Potential clinical value of in vitro spermatogenesis," Biology of Reproduction 107(1), 95-100, (27 April 2022). https://doi.org/10.1093/biolre/ioac076
Received: 29 December 2021; Accepted: 12 April 2022; Published: 27 April 2022
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KEYWORDS
infertility
ntESCs
PGCLCs
spermatogenesis
testicular organogenesis
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