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25 May 2022 Advances in haploid embryonic stem cell research
Chao Liu, Wei Li
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Abstract

Haploid embryonic stem cells are embryonic stem cells of a special type. Their nuclei contain one complete set of genetic material, and they are capable of self-renewal and differentiation. The emergence of haploid embryonic stem cells has aided research in functional genomics, genetic imprinting, parthenogenesis, genetic screening, and somatic cell nuclear transfer. This article reviews current issues in haploid stem cell research based on reports published in recent years and assesses the potential applications of these cells in somatic cell nuclear transfer, genome imprinting, and parthenogenesis.

Summary Sentence

Haploid embryonic stem cells represent a powerful tool for life science research that can be used in genetic screening, functional genomics, somatic cell nuclear transfer, parthenogenesis, and heterozygous cell research.

© The Author(s) 2022. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Chao Liu and Wei Li "Advances in haploid embryonic stem cell research," Biology of Reproduction 107(1), 250-260, (25 May 2022). https://doi.org/10.1093/biolre/ioac110
Received: 25 January 2022; Accepted: 25 May 2022; Published: 25 May 2022
JOURNAL ARTICLE
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KEYWORDS
functional genomics
haploid embryonic stem cells
heterozygous cells
imprinting
somatic cell nuclear transfer
unisexual reproduction
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