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9 June 2022 Research progress and application prospects of stable porcine pluripotent stem cells
Jinying Zhang, Minglei Zhi, Dengfeng Gao, Qianqian Zhu, Jie Gao, Gaoxiang Zhu, Suying Cao, Jianyong Han
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Abstract

Pluripotent stem cells (PSCs) harbor the capacity of unlimited self-renewal and multilineage differentiation potential, which are crucial for basic research and biomedical science. Establishment of PSCs with defined features was previously reported from mice and humans, while generation of stable large animal PSCs has experienced a relatively long trial stage and only recently has made breakthroughs. Pigs are regarded as ideal animal models for their similarities in physiology and anatomy to humans. Generation of porcine PSCs would provide cell resources for basic research, genetic engineering, animal breeding, and cultured meat. In this review, we summarize the progress on the derivation of porcine PSCs and reprogramed cells and elucidate the mechanisms of pluripotency changes during pig embryo development. This will be beneficial for understanding the divergence and conservation between different species involved in embryo development and the pluripotent-regulated signaling pathways. Finally, we also discuss the promising future applications of stable porcine PSCs. Even though challenges remain in the field of porcine stem cells, these progress and viewpoints would provide guidance in future research direction.

© The Author(s) 2022. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Jinying Zhang, Minglei Zhi, Dengfeng Gao, Qianqian Zhu, Jie Gao, Gaoxiang Zhu, Suying Cao, and Jianyong Han "Research progress and application prospects of stable porcine pluripotent stem cells," Biology of Reproduction 107(1), 226-236, (9 June 2022). https://doi.org/10.1093/biolre/ioac119
Received: 31 December 2021; Accepted: 30 May 2022; Published: 9 June 2022
JOURNAL ARTICLE
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KEYWORDS
animal breeding
clinical modeling
cultured meat
embryo
epiblast
induced pluripotent stem cells (iPSCs)
pig
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