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4 July 2022 Advances in studying human gametogenesis and embryonic development in China
Qiang Liu, Xi Chen, Jie Qiao
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Abstract

Reproductive medicine in China has developed rapidly since 1988 due to support from the government and scientific exploration. However, the success rate of assisted reproduction technology is around 30–40% and many unknown “black boxes” in gametogenesis and embryo development are still present. With the development of single-cell and low-input sequencing technologies, the network of transcriptome and epigenetic regulation (DNA methylation, chromatin accessibility, and histone modifications) during the development of human primordial germ cells, gametes, and embryos has been investigated in depth. Furthermore, preimplantation genetic testing has also rapidly developed. In this review, we summarize and analyze China's outstanding progress in these fields.

Summary Sentence

An overview of development of human gametes and embryos, including the dynamic changes and its biological significance of transcriptome and epigenetic regulatory networks in human primordial germ cells, gametes, and early embryonic development.

© The Author(s) 2022. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Qiang Liu, Xi Chen, and Jie Qiao "Advances in studying human gametogenesis and embryonic development in China," Biology of Reproduction 107(1), 12-26, (4 July 2022). https://doi.org/10.1093/biolre/ioac134
Received: 21 January 2022; Accepted: 20 June 2022; Published: 4 July 2022
JOURNAL ARTICLE
15 PAGES


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KEYWORDS
embryo
epigenetic regulatory networks
gametes
human
transcriptome
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