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1 September 2000 IL-15 Expression at Human Endometrium and Decidua
Kotaro Kitaya, Jinsuke Yasuda, Izumi Yagi, Yoshihiro Tada, Shinji Fushiki, Hideo Honjo
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Abstract

A large number of natural killer (NK) cells appear in human uterine mucosa during the secretory phase and first trimester pregnancy. We investigated the expression of interleukin (IL)-15, a possible stimulator for these NK cells, in human endometrium and first trimester decidua. Semiquantitative reverse transcriptase-polymerase chain reaction revealed that IL-15 mRNA expression was stronger during the secretory phase and first trimester pregnancy than during the proliferative phase. Immunohistochemistry revealed that immunoreactivity for anti-IL-15 was higher during the secretory phase than it was during the proliferative phase. This was prominent in the perivascular stromal cells around invading spiral arteries during the mid- to late-secretory phase. In first trimester decidua, endothelial cells were also stained as strongly as stromal cells. A membrane-bound IL-15 molecule was detected on the surface of first trimester decidual cells by flow cytometry. Progesterone stimulated the release of soluble IL-15 in the supernatant of cultured decidual cells. These results suggest that IL-15 expression in human uterine mucosa corresponds to the fluctuation of uterine NK cells and that its production is hormonally controlled, especially by progesterone.

Kotaro Kitaya, Jinsuke Yasuda, Izumi Yagi, Yoshihiro Tada, Shinji Fushiki, and Hideo Honjo "IL-15 Expression at Human Endometrium and Decidua," Biology of Reproduction 63(3), 683-687, (1 September 2000). https://doi.org/10.1095/biolreprod63.3.683
Received: 22 December 1999; Accepted: 1 April 2000; Published: 1 September 2000
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