Viewpoint on the Functionality of the Human Leukocyte Antigen-G Null Allele at the Fetal-Maternal Interface

Philippe Moreau; Jean Dausset; Edgardo D. Carosella; Nathalie Rouas-Freiss

doi:10.1095/biolreprod.102.005439

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Philippe Moreau,¹ Jean Dausset,² Edgardo D. Carosella,^1,* Nathalie Rouas-Freiss¹

¹aService de Recherches en Hémato-Immunologie, CEA-DSV-DRM, Hôpital St-Louis, Institut Universitaire
²bFondation Jean Dausset, CEPH, 75010 Paris, France

^*Correspondence: Edgardo D. Carosella, Service de Recherches en Hémato-Immunologie, CEA-DSV-DRM, Hôpital St-Louis, Institut Universitaire d'Hématologie, 1 avenue Claude Vellefaux, 75475 Paris, Cedex 10, France. FAX: 33 1 48 03 19 60; carosella@dsvidf.cea.fr

Abstract

The description of healthy individuals homozygous for the human leukocyte antigen-G (HLA-G) null allele raised doubts about the role of HLA-G in fetal-maternal tolerance. In light of recent results, we discuss this point by considering the potential activity of this null allele that might, indeed, produce functional truncated HLA-G molecules. In this context, we have recently described that, like the full-length HLA-G1, the HLA-G2, -G3, and -G4 truncated isoforms may be expressed at the cell surface and may modulate both innate and acquired immune responses.

Citation Download Citation

Philippe Moreau, Jean Dausset, Edgardo D. Carosella, and Nathalie Rouas-Freiss "Viewpoint on the Functionality of the Human Leukocyte Antigen-G Null Allele at the Fetal-Maternal Interface," Biology of Reproduction 67(5), 1375-1378, (1 October 2002). https://doi.org/10.1095/biolreprod.102.005439

Received: 12 March 2002; Accepted: 1 June 2002; Published: 1 October 2002

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