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1 February 2003 MuERV-L Is One of the Earliest Transcribed Genes in Mouse One-Cell Embryos
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Abstract

The expression pattern and function of the murine endogenous retrovirus-like (MuERV-L) gene in mouse preimplantation embryos was investigated. MuERV-L was rapidly transcribed from the beginning of S phase (8 h after fertilization) in the first cell cycle. MuERV-L expression was completely repressed when transcription from the zygotic genome was inhibited by α-amanitin. These results reveal that MuERV-L is transcribed from the zygotic genome and that it is expressed earlier than any other genes previously reported. In addition, MuERV-L was expressed even when the first round of DNA synthesis was inhibited by aphidicolin, suggesting that its expression is controlled by the zygotic clock. The function of MuERV-L in the development of mouse embryos was also examined using antisense oligonucleotides. The developmental competence of embryos was markedly suppressed after the 4-cell stage when they were treated with antisense oligonucleotides. This result suggests that MuERV-L plays an important role in the development of mouse embryos at the early preimplantation stage.

Daisuke Kigami, Naojiro Minami, Hanae Takayama, and Hiroshi Imai "MuERV-L Is One of the Earliest Transcribed Genes in Mouse One-Cell Embryos," Biology of Reproduction 68(2), 651-654, (1 February 2003). https://doi.org/10.1095/biolreprod.102.007906
Received: 29 May 2002; Accepted: 1 September 2002; Published: 1 February 2003
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