Translator Disclaimer
1 August 2003 Hierarchical Phenotypic and Epigenetic Variation in Cloned Swine
Greg S. Archer, Scott Dindot, Ted H. Friend, Shawn Walker, Gretchen Zaunbrecher, Bruce Lawhorn, Jorge A. Piedrahita
Author Affiliations +
Abstract

Cloning by somatic cell nuclear transfer can result in the birth of animals with phenotypic and gene expression abnormalities. We compared adult cloned pigs and adult pigs from naturally bred control females using a series of physiological and genetic parameters, including detailed methylation profiles of selected genomic regions. Phenotypic and genetic analyses indicated that there are two classes of traits, one in which the cloned pigs have less variation than controls and another characterized by variation that is equally high in cloned and control pigs. Although cloning creates animals within the normal phenotypic range, it increases the variability associated with some traits. This finding is contrary to the expectation that cloning can be used to reduce the size of groups involved in animal experimentation and to reproduce an animal, including a pet, with a homogenous set of desired traits.

Greg S. Archer, Scott Dindot, Ted H. Friend, Shawn Walker, Gretchen Zaunbrecher, Bruce Lawhorn, and Jorge A. Piedrahita "Hierarchical Phenotypic and Epigenetic Variation in Cloned Swine," Biology of Reproduction 69(2), 430-436, (1 August 2003). https://doi.org/10.1095/biolreprod.103.016147
Received: 10 February 2003; Accepted: 1 March 2003; Published: 1 August 2003
JOURNAL ARTICLE
7 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top