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1 October 2003 Characterization of the Interleukin-1β System During Porcine Trophoblastic Elongation and Early Placental Attachment
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Conceptus-uterine communication is established during trophoblastic elongation when the conceptus synthesizes and releases estrogen, the maternal recognition signal in the pig. Interleukin-1β (IL-1β) is a differentially expressed gene during rapid trophoblastic elongation in the pig. The current investigation determined conceptus and endometrial changes in gene expression for IL-1β, IL-1 receptor antagonist (IL-1Rant), IL-1 receptor type 1 (IL-1RT1), and IL-1 receptor accessory protein (IL-1RAP) in developing peri- and postimplantation conceptuses as well as uterine endometrium collected from cyclic and pregnant gilts. Conceptus IL-1β gene expression was enhanced during the period of rapid trophoblastic elongation compared with earlier spherical conceptuses, followed by a dramatic decrease in elongated Day 15 conceptuses. IL-1RT1 and IL-1RAP gene expression was greater in Day 12 and 15 filamentous conceptuses compared with earlier morphologies while IL-1Rant gene expression was unchanged by conceptus development. The uterine lumenal content of IL-1β increased during the process of trophoblastic elongation on Day 12. Uterine IL-1β content declined on Day 15, reaching a nadir by Day 18 of pregnancy. IL-1β gene expression in porcine conceptuses was temporally associated with an increase in endometrial IL-1RT1 and IL-1RAP gene expression in pregnant gilts. Endometrial IL-1β and IL-1Rant gene expression were lowest during Days 10–15 of the estrous cycle and pregnancy. The temporal expression of IL-1β during conceptus development and the initiation of conceptus-uterine communication suggests conceptus IL-1β synthesis plays an important role in porcine conceptus elongation and the establishment of pregnancy in the pig.

Jason W. Ross, Jerry R. Malayer, Jerry W. Ritchey, and Rodney D. Geisert "Characterization of the Interleukin-1β System During Porcine Trophoblastic Elongation and Early Placental Attachment," Biology of Reproduction 69(4), 1251-1259, (1 October 2003).
Received: 27 January 2003; Accepted: 1 May 2003; Published: 1 October 2003

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