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1 December 2004 Parathyroid Hormone-Related Protein in Preeclampsia: A Linkage Between Maternal and Fetal Failures
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Abstract

Preeclampsia is a disorder associated with pregnancy that affects both the mother and the fetus. Typical features of the disease are maternal hypertension, proteinuria, and edema as well as fetal growth retardation. Although the etiological details are still being debated, a consensus exists that the starting point is deficient placentation in the first half of pregnancy. The crucial early steps are reduced trophoblast invasiveness and enhanced apoptotic death. In the present review, we demonstrate that parathyroid hormone-related protein is involved not only in the maternal and fetal failures but also in the etiological aspects of the disease. We hypothesize that reduced local production of the peptide is a major causative event.

Emanuela Maioli, Vittoria Fortino, and Adriana Pacini "Parathyroid Hormone-Related Protein in Preeclampsia: A Linkage Between Maternal and Fetal Failures," Biology of Reproduction 71(6), 1779-1784, (1 December 2004). https://doi.org/10.1095/biolreprod.104.030932
Received: 14 April 2004; Accepted: 1 July 2004; Published: 1 December 2004
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