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1 February 2005 Blockade of CD86 Signaling Facilitates a Th2 Bias at the Maternal-Fetal Interface and Expands Peripheral CD4 CD25 Regulatory T Cells to Rescue Abortion-Prone Fetuses
Xiao-Yong Zhu, Yue-Hua Zhou, Ming-Yan Wang, Li-Ping Jin, Min-Min Yuan, Da-Jin Li
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Abstract

Intervention in B7 (CD80/CD86)/B7-ligand (CD28/CTLA-4) pathways is an effective way of preventing unwanted immune responses, such as allograft rejection. Pregnancy maintenance represents maternal tolerance to the fetal allograft, which is accompanied by a type 2 helper cell (Th2) bias at the maternal-fetal interface. Here, the costimulatory signal of CD86 was selectively blocked, and that of CD80 was kept unimpaired by administration of anti-murine CD86 monoclonal antibody at the early gestational stage in abortion-prone CBA/J×DBA/2 matings and normal pregnant CBA/J×BALB/c matings. It was demonstrated that in vivo blockade of CD86 costimulation could suppress maternal immune attack to the fetus by shifting cytokines from Th1 predominance to Th2 bias at the maternal-fetal interface, and expanding peripheral CD4 CD25 regulatory T cells, which play an important role in the development and maintenance of maternal-fetal tolerance. Furthermore, the expression of CD28 and its ligands CD80/CD86 on peripheral lymphocytes was down-regulated, whereas that of CTLA-4 was up-regulated, which might facilitate the suppressive effect of CD4 CD25 regulatory T cells on the alloreactive T cells. The maternal-fetal immunotolerance induced by CD86 blockade decreased fetal resorption in CBA/J×DBA/2 matings, but did not affect normal pregnant CBA/J×BALB/c matings. These results suggest that selective blockade of CD86 costimulation leads to maternal immune tolerance to embryo antigen, and might contribute to a rational immunoregulatory regimen for recurrent spontaneous abortion.

Xiao-Yong Zhu, Yue-Hua Zhou, Ming-Yan Wang, Li-Ping Jin, Min-Min Yuan, and Da-Jin Li "Blockade of CD86 Signaling Facilitates a Th2 Bias at the Maternal-Fetal Interface and Expands Peripheral CD4 CD25 Regulatory T Cells to Rescue Abortion-Prone Fetuses," Biology of Reproduction 72(2), 338-345, (1 February 2005). https://doi.org/10.1095/biolreprod.104.034108
Received: 7 July 2004; Accepted: 1 September 2004; Published: 1 February 2005
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