Translator Disclaimer
1 February 2006 Orchitis: A Complication of Severe Acute Respiratory Syndrome (SARS)
Author Affiliations +
Abstract

Severe acute respiratory syndrome (SARS) coronavirus has been known to damage multiple organs; however, little is known about its impact on the reproductive system. In the present study, we analyzed the pathological changes of testes from six patients who died of SARS. Results suggested that SARS caused orchitis. All SARS testes displayed widespread germ cell destruction, few or no spermatozoon in the seminiferous tubule, thickened basement membrane, and leukocyte infiltration. The numbers of CD3 T lymphocytes and CD68 macrophages increased significantly in the interstitial tissue compared with the control group (P < 0.05). SARS viral genomic sequences were not detected in the testes by in situ hybridization. Immunohistochemistry demonstrated abundant IgG precipitation in the seminiferous epithelium of SARS testes, indicating possible immune response as the cause for the damage. Our findings indicated that orchitis is a complication of SARS. It further suggests that the reproductive functions should be followed and evaluated in recovered male SARS patients.

Jian Xu, Lihua Qi, Xiaochun Chi, Jingjing Yang, Xiaohong Wei, Encong Gong, Suatcheng Peh, and Jiang Gu "Orchitis: A Complication of Severe Acute Respiratory Syndrome (SARS)," Biology of Reproduction 74(2), 410-416, (1 February 2006). https://doi.org/10.1095/biolreprod.105.044776
Received: 21 June 2005; Accepted: 1 October 2005; Published: 1 February 2006
JOURNAL ARTICLE
7 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top