Mice Deficient for a Small Cluster of Piwi-Interacting RNAs Implicate Piwi-Interacting RNAs in Transposon Control1

Mingang Xu; Yun You; Patricia Hunsicker; Tamaki Hori; Chris Small; Michael D. Griswold; Norman B. Hecht

doi:10.1095/biolreprod.108.068072

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9 April 2008 Mice Deficient for a Small Cluster of Piwi-Interacting RNAs Implicate Piwi-Interacting RNAs in Transposon Control

Mingang Xu, Yun You, Patricia Hunsicker, Tamaki Hori, Chris Small, Michael D. Griswold, Norman B. Hecht

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Mingang Xu,¹ Yun You,² Patricia Hunsicker,² Tamaki Hori,¹ Chris Small,³ Michael D. Griswold,³ Norman B. Hecht^1,*

¹aCenter for Research on Reproduction and Women's Health,3 University of Pennsylvania School of Medic
²b Life Sciences Division,4 Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830-6942
³c Department of Molecular Biosciences,5 Washington State University, Pullman, Washington 99164-4660

^*Norman B. Hecht, Center for Research on Reproduction and Women's Health, University of Pennsylvania School of Medicine, 1310 Biomedical Research Building, 421 Curie Blvd., Philadelphia, PA 19104-6080. FAX: 215 573 7627; e-mail: nhecht@mail.med.upenn.edu

Biology of Reproduction, 79(1):51-57 (2008). https://doi.org/10.1095/biolreprod.108.068072

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Abstract

The mammalian testis expresses a class of small noncoding RNAs that interact with mammalian PIWI proteins. In mice, the PIWI-interacting RNAs (piRNAs) partner with mammalian PIWI proteins, PIWIL1 and PIWIL2, also known as MIWI and MILI, to maintain transposon silencing in the germline genome. Here, we demonstrate that inactivation of Nct1/2, two noncoding RNAs encoding piRNAs, leads to derepression of LINE-1 (L1) but does not affect mouse viability, spermatogenesis, testicular gene expression, or fertility. These findings indicate that piRNAs from a cluster on chromosome 2 are necessary to maintain transposon silencing.

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Mingang Xu, Yun You, Patricia Hunsicker, Tamaki Hori, Chris Small, Michael D. Griswold, and Norman B. Hecht "Mice Deficient for a Small Cluster of Piwi-Interacting RNAs Implicate Piwi-Interacting RNAs in Transposon Control," Biology of Reproduction 79(1), 51-57, (9 April 2008). https://doi.org/10.1095/biolreprod.108.068072

Received: 31 January 2008; Accepted: 1 March 2008; Published: 9 April 2008

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Biology of Reproduction
Vol. 79 • No. 1
July 2008

KEYWORDS

gametogenesis

gene regulation

male reproductive tract

piRNA

spermatogenesis

testis

transposon

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Mingang Xu, Yun You, Patricia Hunsicker, Tamaki Hori, Chris Small, Michael D. Griswold, Norman B. Hecht "Mice Deficient for a Small Cluster of Piwi-Interacting RNAs Implicate Piwi-Interacting RNAs in Transposon Control," Biology of Reproduction, 79(1), 51-57, (9 April 2008)

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