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1 August 2008 Age-Dependent Loss of Sperm Production in Mice via Impaired Lysophosphatidic Acid Signaling
Xiaoqin Ye, Michael K. Skinner, Grace Kennedy, Jerold Chun
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Abstract

Approximately half of all infertility cases can be attributed to male reproductive dysfunction for which low sperm count is a major contributing factor. The current study identified receptor-mediated lysophosphatidic acid (LPA) signaling as a new molecular component influencing male fertility. LPA is a small signaling phospholipid, the effects of which are mediated through at least five G protein-coupled receptors, named LPA 1–5. LPA1/2/3, but not LPA4/5, show high expression in mouse testis. Mice deficient in LPA1/2/3 showed a testosterone-independent reduction of mating activity and sperm production, with an increased prevalence of azoospermia in aging animals. A significant increase of germ cell apoptosis also was observed in testes. Germ cell apoptosis led to a reduction in germ cell proliferation. These data demonstrate a novel in vivo function for LPA signaling as a germ cell survival factor during spermatogenesis.

Xiaoqin Ye, Michael K. Skinner, Grace Kennedy, and Jerold Chun "Age-Dependent Loss of Sperm Production in Mice via Impaired Lysophosphatidic Acid Signaling," Biology of Reproduction 79(2), 328-336, (1 August 2008). https://doi.org/10.1095/biolreprod.108.068783
Received: 29 February 2008; Accepted: 1 April 2008; Published: 1 August 2008
JOURNAL ARTICLE
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KEYWORDS
germ cell apoptosis and proliferation
LPA and S1P
sperm count
spermatogenesis
testis
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