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5 January 2011 Expression of Variant Ribosomal RNA Genes in Mouse Oocytes and Preimplantation Embryos
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Abstract

Ribosomal DNA (rDNA) is not composed of multiple copies of identical transcription units, as commonly believed, but rather of at least seven rDNA variant subtypes that are expressed in somatic cells. This finding raises the possibility that ribosome function may be modulated as proposed by the ribosome filter hypothesis. We report here that mouse oocytes and preimplantation embryos express all the rDNA variants except variant V and that there is no marked developmental change in the qualitative pattern of variant expression. The maternal and embryonic ribosome pools are therefore quite similar, minimizing the likelihood that developmental changes in composition of the ribosome population are critical for preimplantation development.

Motomasa Ihara, Hung Tseng, and Richard M. Schultz "Expression of Variant Ribosomal RNA Genes in Mouse Oocytes and Preimplantation Embryos," Biology of Reproduction 84(5), 944-946, (5 January 2011). https://doi.org/10.1095/biolreprod.110.089680
Received: 9 November 2010; Accepted: 1 January 2011; Published: 5 January 2011
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