Translator Disclaimer
5 October 2011 Temporal Differences in Granulosa Cell Specification in the Ovary Reflect Distinct Follicle Fates in Mice
Author Affiliations +
Abstract

The embryonic origins of ovarian granulosa cells have been a subject of debate for decades. By tamoxifen-induced lineage tracing of Foxl2-expressing cells, we show that descendants of the bipotential supporting cell precursors in the early gonad contribute granulosa cells to a specific population of follicles in the medulla of the ovary that begin to grow immediately after birth. These precursor cells arise from the proliferative ovarian surface epithelium and enter mitotic arrest prior to upregulating Foxl2. Granulosa cells that populate the cortical primordial follicles activated in adult life derive from the surface epithelium perinatally, and enter mitotic arrest at that stage. Ingression from the surface epithelium dropped to undetectable levels by Postnatal Day 7, when most surviving oocytes were individually encapsulated by granulosa cells. These findings add complexity to the standard model of sex determination in which the Sertoli and granulosa cells of the adult testis and ovary directly stem from the supporting cell precursors of the bipotential gonad.

© 2012 by the Society for the Study of Reproduction, Inc.
Lindsey Mork, Danielle M. Maatouk, Jill A. McMahon, Jin Jin Guo, Pumin Zhang, Andrew P. McMahon, and Blanche Capel "Temporal Differences in Granulosa Cell Specification in the Ovary Reflect Distinct Follicle Fates in Mice," Biology of Reproduction 86(2), (5 October 2011). https://doi.org/10.1095/biolreprod.111.095208
Received: 29 July 2011; Accepted: 1 September 2011; Published: 5 October 2011
JOURNAL ARTICLE
PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top