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9 November 2011 Initiating Meiosis: The Case for Retinoic Acid
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Abstract

The requirement for vitamin A in reproduction and development was first determined from studies of nutritional deficiencies. Subsequent research has shown that embryonic development and both male and female reproduction are modulated by retinoic acid (RA), the active form of vitamin A. Because RA is active in multiple developmental systems, its synthesis, transport, and degradation are tightly regulated in different tissues. A growing body of evidence implicates RA as a requirement for the initiation of meiosis in both male and female mammals, resulting in a mechanistic model involving the interplay of RA, RA synthesis enzymes, RA receptors, and degradative cytochrome P450 enzymes in this system. Recently, that model has been challenged, prompting a review of the established paradigm. While it remains possible that additional molecules may be involved in regulating entry into meiosis, the weight of evidence supporting a key role for RA is incontrovertible.

© 2012 by the Society for the Study of Reproduction, Inc.
Michael D. Griswold, Cathryn A. Hogarth, Josephine Bowles, and Peter Koopman "Initiating Meiosis: The Case for Retinoic Acid," Biology of Reproduction 86(2), (9 November 2011). https://doi.org/10.1095/biolreprod.111.096610
Received: 26 September 2011; Accepted: 1 October 2011; Published: 9 November 2011
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