Translator Disclaimer
6 August 2014 Influence of AKT on Progesterone Action in Endometrial Diseases
Author Affiliations +
Abstract

Progesterone plays an essential role in the maintenance of the endometrium; it prepares the endometrium for pregnancy, promotes decidualization, and inhibits estrogen-dependent proliferation. Progesterone function is often dysregulated in endometrial disease states. In addition, the PI3K/AKT signaling pathway is often overactive in endometrial pathologies and promotes the survival and proliferation of the diseased cells. Understanding how AKT influences progesterone action is critical in improving hormone-based therapies in endometrial pathologies. Here, we summarize recent studies investigating the crosstalk between the AKT pathway and progesterone receptor function in endometriosis and endometrial cancer.

Irene I. Lee and J. Julie Kim "Influence of AKT on Progesterone Action in Endometrial Diseases," Biology of Reproduction 91(3), (6 August 2014). https://doi.org/10.1095/biolreprod.114.119255
Received: 11 March 2014; Accepted: 1 July 2014; Published: 6 August 2014
JOURNAL ARTICLE
PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top