Translator Disclaimer
3 September 2014 The Human Endometrium as a Sensor of Embryo Quality
Nick S. Macklon, Jan J. Brosens
Author Affiliations +
Abstract

Human reproduction is characterized by a high degree of embryo wastage, which is largely ascribed to a high prevalence of embryo aneuploidy. It is proposed that maternal strategies have evolved that prevent inappropriate investment in invasive, but poorly viable embryos. Key to this is the emerging concept of the endometrium as biosensor, first identified in human in vitro embryo/decidualized stromal cell coculture systems and recently confirmed in an in vivo mouse model. In this review, the growing supporting experimental evidence for the biosensor component of decidualized endometrium is outlined, and recent insights into the nature of the embryo-derived signal detected by the endometrium and the biological processes by which this signal is thought to be converted into a go or no-go endometrial response are described. Finally, the clinical implications of this new paradigm of the choosy uterus are addressed.

Nick S. Macklon and Jan J. Brosens "The Human Endometrium as a Sensor of Embryo Quality," Biology of Reproduction 91(4), (3 September 2014). https://doi.org/10.1095/biolreprod.114.122846
Received: 26 June 2014; Accepted: 1 August 2014; Published: 3 September 2014
JOURNAL ARTICLE
PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top