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25 February 2015 Emerging Methods to Generate Artificial Germ Cells from Stem Cells
Fanhui Zeng, Fajun Huang, Jingjing Guo, Xingchang Hu, Changbai Liu, Hu Wang
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Abstract

Germ cells are responsible for the transmission of genetic and epigenetic information across generations. At present, the number of infertile couples is increasing worldwide; these infertility problems can be traced to environmental pollutions, infectious diseases, cancer, psychological or work-related stress, and other factors, such as lifestyle and genetics. Notably, lack of germ cells and germ cell loss present real obstacles in infertility treatment. Recent research aimed at producing gametes through artificial germ cell generation from stem cells may offer great hope for affected couples to treat infertility in the future. Therefore, this rapidly emerging area of artificial germ cell generation from nongermline cells has gained considerable attention from basic and clinical research in the fields of stem cell biology, developmental biology, and reproductive biology. Here, we review the state of the art in artificial germ cell generation.

Fanhui Zeng, Fajun Huang, Jingjing Guo, Xingchang Hu, Changbai Liu, and Hu Wang "Emerging Methods to Generate Artificial Germ Cells from Stem Cells," Biology of Reproduction 92(4), (25 February 2015). https://doi.org/10.1095/biolreprod.114.124800
Received: 5 September 2014; Accepted: 1 February 2015; Published: 25 February 2015
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KEYWORDS
differentiation
gamete biology
gametogenesis
germ cells
germline
infertility
stem cells
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