Translator Disclaimer
11 May 2016 An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline
Winifred Mak, Caodi Fang, Tobias Holden, Milana Bockhur Dratver, Haifan Lin
Author Affiliations +
Abstract

Pumilio/FBF (PUF) proteins are a highly conserved family of translational regulators. The Drosophila PUF protein, Pumilio, is crucial for germline establishment and fertility. In mammals, primordial folliculogenesis is a key process that establishes the initial cohort of female mammalian germ cells prior to birth, and this primordial follicle pool is a prerequisite for female reproductive competence. We sought to understand whether PUF proteins have a conserved role in mammals during primordial folliculogenesis and female reproductive competency. In mammals, two homologs of Pumilio exist: Pumilio 1 (Pum1) and Pum2. Here, we report that PUMILIO (PUM) 1 plays an important role in the establishment of the primordial follicle pool, meiosis, and female reproductive competency, whereas PUM2 does not have a detectable function in these processes. Furthermore, we show that PUM1 facilitates the transition of the late meiotic prophase I oocyte from pachytene to diplotene stage by regulating SYCP1 protein. Our study reveals an important role of translational regulation in mammalian female germ cell development.

Winifred Mak, Caodi Fang, Tobias Holden, Milana Bockhur Dratver, and Haifan Lin "An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline," Biology of Reproduction 94(6), (11 May 2016). https://doi.org/10.1095/biolreprod.115.137497
Received: 1 December 2015; Accepted: 1 May 2016; Published: 11 May 2016
JOURNAL ARTICLE
PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top