20 December 2016 Signaling mechanisms in mammalian sperm motility
Maria João Freitas, Srinivasan Vijayaraghavan, Margarida Fardilha
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The goal of sperm is to fertilize the oocyte. To achieve that purpose, it must acquire motility in the epididymis and hyperactivated motility in the female reproductive tract. Motility is only achieved when the sperm presents a fully functional flagellum, is capable of producing energy to fuel the movement, and suffers epididymal maturation and capacitation. Since sperm is a transcriptionally silent cell, motility depends on the activation and/or inhibitions of key signaling pathways. This review describes and discusses the main signaling pathways involved in primary and hyperactivated motility, as well as the bioenergetic mechanisms necessary to produce energy to fuel sperm motility. Although the complete human spermmotility process is far from being fully known, we believe that in the upcoming decades extensive progress will be made. Understanding the signaling pathways behind sperm motility can help pinpoint the cause of male infertility and uncover targets for male contraception.

Summary Sentence

Sperm motility depends on energy availability, intact flagellum and the crosstalk of several signaling pathways that lead to an increase of tyrosine phosphorylation of key proteins.

© The Authors 2016. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please journals.permissions@oup.com
Maria João Freitas, Srinivasan Vijayaraghavan, and Margarida Fardilha "Signaling mechanisms in mammalian sperm motility," Biology of Reproduction 96(1), 2-12, (20 December 2016). https://doi.org/10.1095/biolreprod.116.144337
Received: 23 August 2016; Accepted: 22 November 2016; Published: 20 December 2016
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