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22 December 2016 Immune response to a model shared placenta/tumor-associated antigen reduces cancer risk in parous mice
Susmita Jasti, Mina Farahbakhsh, Sean Nguyen, Brian K. Petroff, Margaret G. Petroff
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Abstract

During human pregnancy, paternally inherited antigens expressed by the fetal–placental unit can elicit expansion of antigen-specific CD8+T cells. These cells can persist for years asmemory T cells, but their effects on long-term maternal health are unknown. Shared placenta/tumor-associated antigens are expressed by placenta and tumors, but areminimally expressed or absent in normal adult tissues. We hypothesized that maternal T cells elicited against these antigens can alter risk of cancers expressing the same antigen after pregnancy, and tested this inmice using chicken ovalbumin (OVA) as a surrogate shared placenta/tumor antigen. Hemizygous OVA transgenicmales were bred to wild-type C57BL/6 females (H2b haplotype) such that the fetuses inherited and expressed OVA. Maternal OVA/H2Kb-specific CD8+ T cells became detectable during gestation, and persisted in some animals for up to 24 weeks. To determine whether these cells might influence growth of OVA-expressing tumors in OVA-bred females, E.G7-OVA thymoma cells were inoculated subcutaneously in OVA-bred, wild-type bred, and virgin females, and monitored for growth. OVA-bred mice had prolonged survival as compared to virgin mice and the progression of tumors was delayed in comparison to wild-type bred and virgin females. Thus, paternally inherited OVA antigen elicited a CD8+ T cell response during pregnancy that was associated with delayed growth of OVA-expressing tumors following pregnancy. These data suggest a possible role of antigen-specific T cells in protecting parous females against tumors bearing shared placenta/tumor antigens.

Summary Sentence

Gestational exposure of shared placenta/tumor-associated antigen may induce antigen-specific T cells, which may lower cancer risk against tumors bearing same antigen.

© The Authors 2016. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Susmita Jasti, Mina Farahbakhsh, Sean Nguyen, Brian K. Petroff, and Margaret G. Petroff "Immune response to a model shared placenta/tumor-associated antigen reduces cancer risk in parous mice," Biology of Reproduction 96(1), 134-144, (22 December 2016). https://doi.org/10.1095/biolreprod.116.144907
Received: 13 September 2016; Accepted: 15 November 2016; Published: 22 December 2016
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