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24 January 2017 Assisted reproductive technologies in the common marmoset: an integral species for developing nonhuman primate models of human diseases
Jenna Kropp, Andrea Di Marzo, Thaddeus Golos
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Abstract

Generation of nonhuman primate models of human disease conditions will foster the development of novel therapeutic strategies. Callithrix jacchus, or the common marmoset, is a New World, nonhuman primate species that exhibits great reproductive fitness in captivity with an ovarian cycle that can be easily managed with pharmacological agents. This characteristic, among others, provides an opportunity to employ assisted reproductive technologies to generate embryos that can be genetically manipulated to create a variety of nonhuman primate models for human disease. Here, we review methods to synchronize the marmoset ovarian cycle and stimulate oocyte donors, and compare various protocols for in vitro production of embryos. In light of advances in genomic editing, recent approaches used to generate transgenic or genetically edited embryos in the marmoset and also future perspective are reviewed.

Summary Sentence

This review presents a summary of assisted reproductive technologies utilized to generate in vitro produced embryos in the common marmoset and describes prospects for genomic editing and transgenesis to create nonhuman primate models of human disease.

© The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please journals.permissions@oup.com
Jenna Kropp, Andrea Di Marzo, and Thaddeus Golos "Assisted reproductive technologies in the common marmoset: an integral species for developing nonhuman primate models of human diseases," Biology of Reproduction 96(2), 277-287, (24 January 2017). https://doi.org/10.1095/biolreprod.116.146514
Received: 1 November 2016; Accepted: 5 January 2017; Published: 24 January 2017
JOURNAL ARTICLE
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