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25 February 2017 Regulatory effects of autophagy on spermatogenesis
Jun Yin, Bing Ni, Zhi-qiang Tian, Fan Yang, Wei-gong Liao, Yu-qi Gao
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Abstract

Abnormal spermatogenesis is an important pathophysiological process underlying male infertility. Apoptosis of spermatogenic cells and disruption of ectoplasmic specialization (ES) have been characterized as the key biological events of this disorder. Under physiological and pathophysiological conditions (such as exposure to starvation, environmental chemicals, radiation), autophagy is activated in spermatogenic or Sertoli cells in order to maintain survival of the spermatogenic cells by inhibiting spermatogenic cell apoptosis and stabilizing the integrity of ES via degradation of PDZ and LIM domain 1 (PDLIM1), a negative regulator of cytoskeletal organization. Here, we review the most recent research progress towards understanding the pivotal effects of autophagy on spermatogenesis.

Summary Sentence

Autophagy plays a prosurvival role in spermatogenic cells and promotes stabilization of the integrity of ES, either by directly inhibiting apoptosis of spermatogenic cells and degrading PDLIM1 or indirectly by suppressing intracellular stressors.

© The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Jun Yin, Bing Ni, Zhi-qiang Tian, Fan Yang, Wei-gong Liao, and Yu-qi Gao "Regulatory effects of autophagy on spermatogenesis," Biology of Reproduction 96(3), 525-530, (25 February 2017). https://doi.org/10.1095/biolreprod.116.144063
Received: 8 August 2016; Accepted: 30 January 2017; Published: 25 February 2017
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