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30 June 2017 Plasma anti-Müllerian hormone profile in heifers from birth through puberty and relationship with puberty onset
Hossam El-Sheikh Ali, Go Kitahara, Toru Takahashi, Shogo Mido, Mohammed Sadawy, Ikuo Kobayashi, Koichiro Hemmi, Takeshi Osawa
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Abstract

The current study aimed to define the plasma profile of anti-Müllerian hormone (AMH) and follicle stimulating hormone (FSH) in heifers during postnatal life until achieving puberty, as defined by plasma progesterone (P4) profile, to demonstrate a relationship between AMH and age of puberty onset. Blood samples collected from 11 Japanese Black female calves within 1 week after birth (W 0) and then biweekly until the sixth week after puberty (WP 6) were assayed for AMH, FSH, and P4. The heifers were classified into two groups based on age of puberty onset: ≤42 weeks (early puberty group; EP, n = 4) and ≥44 weeks (late puberty group; LP, n = 7). Minimal plasma AMH concentration occurring at W 0 gradually increased to its peak level by W 10 (fourfold higher than W 0; P < 0.01) before gradually declining to a steady plateau 6 weeks before puberty (WP -6). The AMH peak was preceded by a significant rise in plasma FSH at W 4, W 6, and W 8 compared with W0. Plasma AMH atW16 positively correlated withWP 4 andWP 6 (r = 0.69 and 0.71, respectively; P < 0.05). Overall plasma AMH and FSH was significantly higher and lower in EP compared with LP, respectively. In conclusion, heifers exhibit a characteristic plasma AMH profile during postnatal life, such that plasma AMH at an early prepubertal age could be a biomarker for precocious puberty and postpubertal AMH levels.

Summary Sentence

Plasma anti-Müllerian hormone (AMH) follows a characteristic profile in heifers during the postnatal period until puberty. Quantifying plasma AMH at early prepubertal age could be a useful biomarker for precocious puberty and postpubertal AMH levels.

© The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Hossam El-Sheikh Ali, Go Kitahara, Toru Takahashi, Shogo Mido, Mohammed Sadawy, Ikuo Kobayashi, Koichiro Hemmi, and Takeshi Osawa "Plasma anti-Müllerian hormone profile in heifers from birth through puberty and relationship with puberty onset," Biology of Reproduction 97(1), 153-161, (30 June 2017). https://doi.org/10.1093/biolre/iox069
Received: 15 March 2017; Accepted: 28 June 2017; Published: 30 June 2017
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