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21 July 2017 New hope for symptom management during natural and iatrogenic menopause transitions
Teresa K. Woodruff, Sundeep Khosla
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Bone loss is associated with aging and is exacerbated by female transition tomenopause. Estrogen has long been associated with bone loss, and replacement therapy is effective at restoring bone health. In the last 10 years, pituitary and gonadal peptide hormones have been implicated in bone biology, and here we update the story on FSH and its potential role as a direct regulator of bone and adipose. If translated to humans, new approaches to ameliorate age related bone demise could be developed. Moreover, young women with hormone responsive cancers who are unable to maintain bone may have new routes to avoid debilitating bone loss.

Summary Sentence

Bone loss in women could be explained by high FSH and not loss of estradiol.

© The Authors 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail:
Teresa K. Woodruff and Sundeep Khosla "New hope for symptom management during natural and iatrogenic menopause transitions," Biology of Reproduction 97(2), 177-178, (21 July 2017).
Received: 29 June 2017; Accepted: 19 July 2017; Published: 21 July 2017
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