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21 November 2017 Mice with either diminished or elevated levels of anti-Müllerian hormone have decreased litter sizes
Ian S. McLennan, Kyoko Koishi, Nicola J. Batchelor, Michael W. Pankhurst
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Abstract

Anti-Müllerian hormone (AMH) is both a gonadal hormone and a putative paracrine regulator of neurons, the uterus, and the placenta. A mouse line with neuronal expression of AMH (Thy1.2-AMH) was generated to examine the role of paracrine AMH in the brain. The mice had normal behavior, but unexpectantly AMH was present in the circulation of the transgenic mice. Thy1.2-AMHTg/0 studs sired pups with a normal frequency, when mated with wild-type dams. In stark contrast, Thy1.2-AMHTg/0 dams rarely gave birth, with evidence of spontaneous midgestational abortion. This leads to the hypothesis that AMH influences the capacity of dams to carry concepti to term. This hypothesis was tested by mating AMH-deficient (Amh-/-), Thy1.2-AMHTg/0, and wildtype dams when 49-, 80-, and 111 days old, using proven wild-type studs. The litter sizes from the first two matings and the number of fetuses present on the 10th day of gestation of the third mating were recorded. Thy1.2-AMHTg/0 dams carried near normal numbers of midterm fetuses, but typically produced no pups, indicating that extensive late resorption of fetuses was occurring. Amh-/- dams exhibited a lesser reduction in litter size than the Thy1.2-AMHTg/0 dams, with no evidence of enhanced loss of fetuses. In conclusion, this study provides the first evidence that high AMH levels can cause a miscarriage phenotype and that the absence of AMH affects reproductive output.

Summary Sentence

Prevention of the pregnancy-related decline in circulating anti-Müllerian hormone levels leads to midterm abortion.

© The Author(s) 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Ian S. McLennan, Kyoko Koishi, Nicola J. Batchelor, and Michael W. Pankhurst "Mice with either diminished or elevated levels of anti-Müllerian hormone have decreased litter sizes," Biology of Reproduction 98(1), 54-62, (21 November 2017). https://doi.org/10.1093/biolre/iox151
Received: 3 August 2017; Accepted: 17 November 2017; Published: 21 November 2017
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