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8 December 2017 The oviduct: from sperm selection to the epigenetic landscape of the embryo
Serafín Pérez-Cerezales, Priscila Ramos-Ibeas, Omar Salvador Acuña, Manuel Avilés, Pilar Coy, Dimitrios Rizos, Alfonso Gutiérrez-Adán
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Abstract

The mammalian oviduct is the place where life begins as it is the site of fertilization and preimplantation embryo development. Recent research has highlighted the important role played by the oviduct both in sperm selection for natural fertilization and in the genetic and epigenetic reprogramming of preimplantation embryo development. This review examines oviduct fluid composition with a special emphasis on exosomes and the role played by the oviduct in sperm selection, early embryo development, and in reshaping the epigenetic landscape of the embryo. In addition, the implications of data obtained for improving assisted reproductive technologies are discussed.

Summary Sentence

Herein we review the influence of the oviduct on spermatozoa and embryo with special emphasis on the composition of the oviductal flow, sperm selection and remodelling of embryo epigenetics.

© The Author(s) 2017. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Serafín Pérez-Cerezales, Priscila Ramos-Ibeas, Omar Salvador Acuña, Manuel Avilés, Pilar Coy, Dimitrios Rizos, and Alfonso Gutiérrez-Adán "The oviduct: from sperm selection to the epigenetic landscape of the embryo," Biology of Reproduction 98(3), 262-276, (8 December 2017). https://doi.org/10.1093/biolre/iox173
Received: 11 October 2017; Accepted: 7 December 2017; Published: 8 December 2017
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