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5 January 2018 Interleukin 22 prevents lipopolysaccharide-induced preterm labor in mice
Svetlana Dambaeva, Sylvia Schneiderman, Mukesh K Jaiswal, Varkha Agrawal, Gajendra K Katara, Alice Gilman-Sachs, Emmet Hirsch, Kenneth D Beaman
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Abstract

Preterm birth is widespread and causes 35% of all neonatal deaths. Infants who survive face potential long-term complications. A major contributing factor of preterm birth is infection. We investigated the role of interleukin 22 (IL22) as a potential clinically relevant cytokine during gestational infection. IL22 is an effector molecule secreted by immune cells. While the expression of IL22 was reported in normal nonpregnant endometrium and early pregnancy decidua, little is known about uterine IL22 expression during mid or late gestational stages of pregnancy. Since IL22 has been shown to be an essential mediator in epithelial regeneration and wound repair, we investigated the potential role of IL22 during defense against an inflammatory response at the maternal–fetal interface. We used a well-established model to study infection and infection-associated inflammation during preterm birth in the mouse. We have shown that IL22 is upregulated to respond to an intrauterine lipopolysaccharide administration and plays an important role in controlling the risk of inflammation-induced preterm birth. This paper proposes IL22 as a treatment method to combat infection and prevent preterm birth in susceptible patients.

Summary Sentence

IL22 is upregulated in uterine tissue in response to bacterial endotoxin and contributes to defense against inflammatory reaction at the maternal-fetal interface

© The Author(s) 2018. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Svetlana Dambaeva, Sylvia Schneiderman, Mukesh K Jaiswal, Varkha Agrawal, Gajendra K Katara, Alice Gilman-Sachs, Emmet Hirsch, and Kenneth D Beaman "Interleukin 22 prevents lipopolysaccharide-induced preterm labor in mice," Biology of Reproduction 98(3), 299-308, (5 January 2018). https://doi.org/10.1093/biolre/iox182
Received: 1 August 2017; Accepted: 27 December 2017; Published: 5 January 2018
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