Premature progesterone (P) elevation was commonly seen in IVF prior to the utilization of GnRH analogues for suppression of endogenous gonadotropin release. The cause and effect of premature P elevation has finally been better elucidated in the past decade. Although still occurring in 5–38% of all IVF cycles, the adverse effects of premature P elevation on pregnancy outcomes are now well known.
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Vol. 99 • No. 1