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15 June 2018 PDCD4 suppresses proliferation, migration, and invasion of endometrial cells by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway
Yue Li, Xiaoyan Wang, Xishuang Wang, Lu Wan, Yanping Liu, Yongyu Shi, Lining Zhang, Zhenghui Fang, Zengtao Wei
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Abstract

Endometriosis (EM) is a kind of estrogen-dependent disease in reproductive-age women. Ovarian EM is the most common type. Although EM is a benign disease, it shares many similar features with cancers. Programmed cell death 4 (PDCD4), a newly identified tumor suppressor, plays an important role in inhibiting tumorigenesis and tumor progression at the transcriptional and translational levels. To explore the roles of PDCD4 in EM,we detected the expression of PDCD4 in control endometrium and eutopic/ectopic endometrium of ovarian EM patients, and analyzed the effects of PDCD4 on the biological behaviors of endometrial cell lines and primary endometrial cells. The results demonstrated that PDCD4 was downregulated in eutopic and ectopic endometrium of EM patients compared with control endometrium. PDCD4 effectively inhibited the proliferation and colony-forming ability of endometrial cells maybe by inhibiting cell autophagy. In addition, PDCD4 also suppressed the migration and invasion ability of endometrial cells, the mechanism may be related to NF-κB/MMP2/MMP9 signal pathway. Taken together, these results suggest that PDCD4 could be involved in the pathogenesis of EM, and provide a novel approach to target the aberrant PDCD4 expression in EM.

Summary Sentence

PDCD4 suppresses proliferation, migration, and invasion of endometrial cells by the inhibition of autophagy and inactivation of NF-κB/MMP2/MMP9 signal pathway.

© The Author(s) 2018. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Yue Li, Xiaoyan Wang, Xishuang Wang, Lu Wan, Yanping Liu, Yongyu Shi, Lining Zhang, Zhenghui Fang, and Zengtao Wei "PDCD4 suppresses proliferation, migration, and invasion of endometrial cells by inhibiting autophagy and NF-κB/MMP2/MMP9 signal pathway," Biology of Reproduction 99(2), 360-372, (15 June 2018). https://doi.org/10.1093/biolre/ioy052
Received: 14 October 2017; Accepted: 14 June 2018; Published: 15 June 2018
JOURNAL ARTICLE
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