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20 March 2018 Cellular prion protein is involved in decidualization of mouse uterus
Nai-Zheng Ding, Xing-Ming Wang, Xiang-Wen Jiao, Ran Li, Chao Zeng, Shan-Ni Li, Hong-Shan Guo, Ze-You Wang, Zhu Huang, Cheng-Qiang He
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Abstract

Prion protein (PrP) is encoded by a single copy gene Prnp in many cell and tissue types. PrP is very famous for its infectious conformers (PrPSC) resulting in transmissible spongiform encephalopathies. At present, physiological functions of its cellular isoform (PrPC) remain ambiguous. Although PrPC expression has been found in uterus, whether it functions in maternal–fetal dialogue during early pregnant is unknown. In this study, we examined PrPC mRNA and protein in the uterus of peri-implantation mice, and found that they were expressed with a spatiotemporal dynamic pattern. Interestingly, PrPC was significantly increased in the decidual zones around the implanting embryos at the implantation window stage. To further demonstrate that PrPC is involved in the decidualization of mouse uterus during embryo implantation, we constructed the artificial decidualization models and the delayed implantation models. Once the pseudopregnant mice were artificially induced to decidualization, the PrPC expression then increased significantly in the decidua zone. And also, if the delayed implantation embryos were allowed to implant, PrPC protein was also simultaneously improved in stromal cells surrounding the implanting embryos. Moreover, PrPC expression can be inhibited by progesterone but upregulated by estrogen inmouse uterus. These results suggest that PrPC may play an important role in embryo implantation and decidualization.

Summary Sentence

Regulated by estrogen and progesterone, cellular prion protein is expressed with a spatiotemporal manner in peri-implantation mouse uterus, and may play a role in embryo implantation and decidualization.

© The Author(s) 2018. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Nai-Zheng Ding, Xing-Ming Wang, Xiang-Wen Jiao, Ran Li, Chao Zeng, Shan-Ni Li, Hong-Shan Guo, Ze-You Wang, Zhu Huang, and Cheng-Qiang He "Cellular prion protein is involved in decidualization of mouse uterus ," Biology of Reproduction 99(2), 319-325, (20 March 2018). https://doi.org/10.1093/biolre/ioy065
Received: 10 January 2018; Accepted: 19 March 2018; Published: 20 March 2018
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