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24 March 2018 Surfactant protein A suppresses preterm delivery induced by live Escherichia coli in mice
Varkha Agrawal, Mukesh K. Jaiswal, Kenneth D. Beaman, Emmet Hirsch
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Preterm birth accounts for the majority of neonatalmorbidity andmortality in the developed world. A significant proportion of cases of spontaneous preterm labor are attributable to infections within gestational tissues. Surfactant protein A (SP-A), a collectin produced in the fetal lung and other tissues, has been shown previously in mice to suppress preterm delivery due to intrauterine (IU) instillation of sterile proinflammatory substances. Here we report a powerful antilabor effect for SPA after IU infection with live Escherichia coli. SP-A abolished preterm birth (rate reduced from 100% to 0%) when it was administered into the uterus simultaneously with bacterial infection, reducing it by 75% when administered intravenously at the same time as IU bacterial inoculation, and by 48% when administered intravenously 4 h after IU bacterial infection. This effect on preterm delivery was accompanied by a parallel benefit on fetal survival in utero. SP-A had no effect on bacterial growth but reversed several major consequences of infection, including increased production of inflammatory mediators and a shift in macrophage polarization to the M1 phenotype. These findings suggest that exogenous SP-A has potential use to counteract infection-induced labor by reversing its proinflammatory consequences.

Summary Sentence

The fetally produced collectin SP-A has powerful suppressive effects in a mousemodel of infectioninduced preterm delivery.

© The Author(s) 2018. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail:
Varkha Agrawal, Mukesh K. Jaiswal, Kenneth D. Beaman, and Emmet Hirsch "Surfactant protein A suppresses preterm delivery induced by live Escherichia coli in mice," Biology of Reproduction 99(3), 546-555, (24 March 2018).
Received: 2 January 2018; Accepted: 22 March 2018; Published: 24 March 2018
preterm labor
surfactant protein
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