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12 April 2018 Bovine embryo elongation is altered due to maternal fatty acid supplementation
Katrin Giller, Barbara Drews, Joel Berard, Hermine Kienberger, Marion Schmicke, Jan Frank, Britta Spanier, Hannelore Daniel, Gerd Geisslinger, Susanne E. Ulbrich
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Abstract

The pre-implantation period is prone to embryonic losses in bovine. Embryo–maternal communication is crucial to support embryo development. Thereby, factors of the uterine fluid (UF) are of specific importance. The maternal diet can affect the UF composition. Since omega 3 fatty acids (omega 3 FA) are considered to be beneficial for reproduction, we investigated if dietary omega 3 FA affected factors in the UF related to embryo elongation. Angus heifers (n = 37) were supplemented with either 450 g of rumen-protected fish oil (omega 3 FA) or sunflower oil (omega 6 FA) for a period of 8 weeks. Following cycle synchronization and artificial insemination, the uteri were flushed post mortem to recover the embryos on day 15 of pregnancy. The UF and tissue samples of endometrium and corpus luteum (CL) were collected. Strikingly, the embryo elongation in the omega 3 group was enhanced compared to the omega 6 group. No differences were observed in uterine prostaglandins, even though the endometrial concentration of their precursor arachidonic acidwas reduced in omega 3 compared to omega 6 heifers. The dietary FA neither led to differential expression of target genes in endometrium nor CL nor to a differential abundance of low-density lipoprotein cholesterol, cortisol or amino acids in the UF. Interestingly, the omega 3 group displayed a higher plasma progesterone concentration during luteal growth than the omega 6 group, possibly promoting embryo elongation. Further research should include an ovarian perspective to understand the functional link between dietary omega 3 FA and reproductive outcome.

Summary Sentence

The pre-implantation embryo elongation in bovine is affected by dietary omega 3/6 fatty acids likely due to an effect on the ovary rather than a change of the uterine secretome.

© The Author(s) 2018. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Katrin Giller, Barbara Drews, Joel Berard, Hermine Kienberger, Marion Schmicke, Jan Frank, Britta Spanier, Hannelore Daniel, Gerd Geisslinger, and Susanne E. Ulbrich "Bovine embryo elongation is altered due to maternal fatty acid supplementation," Biology of Reproduction 99(3), 600-610, (12 April 2018). https://doi.org/10.1093/biolre/ioy084
Received: 16 November 2017; Accepted: 11 April 2018; Published: 12 April 2018
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