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26 April 2018 Evolution of gonadotropin signaling on gonad development: insights from gene knockout studies in zebrafish
Jianzhen Li, Christopher H.K. Cheng
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Abstract

Gonadal development is precisely regulated by the two gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Much progress on understanding the functions of LH and FSH signaling on gonad development has been achieved in the past decades, mostly from studies in mammals, especially genetic studies in both mouse and human. The functions of both LH and FSH signaling in nonmammalian species are still largely unknown. In recent years, using zebrafish, a teleost phylogenetically distant from mammals, we and others have genetically analyzed the functions of gonadotropins and their receptors through gene knockout studies. In this review, we will summarize the pertinent findings and discuss how the actions of gonadotropin signaling on gonad development have evolved during evolution from fish to mammals.

© The Author(s) 2018. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com
Jianzhen Li and Christopher H.K. Cheng "Evolution of gonadotropin signaling on gonad development: insights from gene knockout studies in zebrafish," Biology of Reproduction 99(4), 686-694, (26 April 2018). https://doi.org/10.1093/biolre/ioy101
Received: 16 February 2018; Accepted: 25 April 2018; Published: 26 April 2018
JOURNAL ARTICLE
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KEYWORDS
evolution
FSH
Fshr
gonad
LH
Lhr
zebrafish
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