Stress has been shown to impact the rate of development in many species of vertebrates, including amphibians, reptiles, and mammals. We investigated how treatments of corticosterone, a glucocorticoid stress hormone, would affect the development and immune function of the Western Chorus Frog (Pseudacris triseriata) and the Southern Leopard Frog (Lithobates sphenocephalus). These two species exhibit different metamorphic rates, and we specifically chose these species as we wanted to determine if stress during development had a different effect on species with substantially different developmental periods. Tadpoles in the treatment group were given doses of corticosterone (0.5 μM in their water) and tadpoles in the control group were not dosed with corticosterone. Following three weeks of treatment, a blood sample was collected from each tadpole for use in a Candida albicans killing assay to test constitutive immunity. The findings suggest that Western Chorus Frog tadpoles and Southern Leopard Frog tadpoles differ significantly in their response to stress, from both a developmental and an immunological standpoint. Western Chorus Frog tadpoles treated with corticosterone developed significantly faster than control tadpoles and had significantly weaker immune responses to the C. albicans challenge. Conversely, there was no significant difference in development in Southern Leopard Frog tadpoles treated with corticosterone compared to controls; however, those given corticosterone had significantly stronger immune responses to the C. albicans challenge. Together, these findings suggest fundamental differences in larval amphibian response to stress that may be related to physiological and ecological restraints in each species.