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1 May 2011 Microbial Communities as Experimental Units
Mitch D. Day, Daniel Beck, James A. Foster
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Abstract

Artificial ecosystem selection is an experimental technique that treats microbial communities as though they were discrete units by applying selection on community-level properties. Highly diverse microbial communities associated with humans and other organisms can have significant impacts on the health of the host. It is difficult to find correlations between microbial community composition and community-associated diseases, in part because it may be impossible to define a universal and robust species concept for microbes. Microbial communities are composed of potentially thousands of unique populations that evolved in intimate contact, so it is appropriate in many situations to view the community as the unit of analysis. This perspective is supported by recent discoveries using metagenomics and pangenomics. Artificial ecosystem selection experiments can be costly, but they bring the logical rigor of biological model systems to the emerging field of microbial community analysis.

© 2011 by American Institute of Biological Sciences. All rights reserved. Request permission to photocopy or reproduce article content at the University of California Press's Rights and Permissions Web site at www.ucpressjournals.com/reprintinfo.asp.
Mitch D. Day, Daniel Beck, and James A. Foster "Microbial Communities as Experimental Units," BioScience 61(5), 398-406, (1 May 2011). https://doi.org/10.1525/bio.2011.61.5.9
Published: 1 May 2011
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