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1 August 2013 RNAi-Based Insecticidal Crops: Potential Effects on Nontarget Species
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Abstract

The potential hazards posed by RNA interference (RNAi)—based pesticides and genetically modified crops to nontarget organisms include off-target gene silencing, silencing the target gene in unintended organisms, immune stimulation, and saturation of the RNAi machinery. Nontarget organisms will vary in their exposure to small RNAs produced by genetically modified crops, but exposure to insecticidal small RNAs will probably occur at a previously unrealized scale for many. Areas that warrant future work include the persistence of insecticidal small RNAs in the environment, describing crop-based food webs to understand those species that are most exposed, sequencing genomes for species to proactively understand those that may be affected by RNAi, and substantiating that laboratory toxicity testing can accurately predict the field-level effects of this technology. The costs and benefits of pesticidal RNA must be considered relative to current pest management options as pesticidal RNAs move from a theoretical approach to being used as a practical tool.

© 2013 by American Institute of Biological Sciences. All rights reserved. Request permission to photocopy or reproduce article content at the University of California Press's Rights and Permissions Web site at www.ucpressjournals.com/reprintinfo.asp.
Jonathan G. Lundgren and Jian J. Duan "RNAi-Based Insecticidal Crops: Potential Effects on Nontarget Species," BioScience 63(8), 657-665, (1 August 2013). https://doi.org/10.1525/bio.2013.63.8.8
Published: 1 August 2013
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