Crassula anso-lerouxiae, a new Crassula species, is described from the Succulent Karoo region between Worcester and Robertson. The linear obovate leaves in oblique pairs are not unlike C. cotyledonis, however, here the resemblance ends. C. anso-lerouxiae is distinguished by its much branched decumbent clustered growth of leaves covered in stiff recurved white trichomes, the margin obtuse and indistinct.