Cotyledon flanaganii Schönl. & Baker f. is re-instated, and a new subspecies Cotyledon flanaganii subsp. mzimvubuensis is described and illustrated from shale cliffs and steep banks along Mzimvubu and Msikaba rivers in the Eastern Cape. It differs from Cotyledon flanaganii subsp. flanaganii by its distinctly linear spathulate, dorsiventrally flattened, sparingly glandular hairy leaves, and dorsiventrally flattened leaf-like bracts on the peduncle becoming smaller upwards. It grows in Eastern Valley Bushveld which is part of the Savanna Biome.