An overview and update is provided of the conservation status of the twenty species of Kalanchoe (Crassulaceae subfam. Kalanchooideae) indigenous in southern Africa. Fourteen of the species grow abundantly in extensive natural geographical distribution ranges and from a conservation perspective are of Least Concern. One species, K. laciniata, has a very wide global distribution range but is restricted to Namibia in the southern African region. The other five Kalanchoe species that are of conservation concern are all southern African endemics, being additionally endemic to specific Regions or Centres of Endemism. These are: K. alticola (Barberton Centre of Endemism), K. crouchii (Wolkberg Centre of Endemism), K. crundallii (Soutpansberg Centre of Endmism), K. longiflora (Maputaland-Pondoland Region of Endemism) and K. winteri (Wolkberg Centre of Endemism).