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1 September 2011 cDNA cloning, characterization and expression analysis of toll-like receptor 4 gene in goose
Fang Wang, Lizhi Lu, Hao Yuan, Yong Tian, Jinjun Li, Junda Shen, Zhengrong Tao, Yan Fu
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Abstract

Wang, F., Lu, L., Yuan, H., Tian, Y., Li, J., Shen, J., Tao, Z. and Fu, Y. 2011. cDNA cloning, characterization and expression analysis of toll-like receptor 4 gene in goose. Can. J. Anim. Sci. 91: 371-377. Toll-like receptor 4 (TLR4) plays an important role in activating proinflammatory pathways in response to various pathogens and fatty acids in mammals. In avian species, the TLR4 gene has been reported in chicken and zebra finch. We describe here the cloning and characterization of the TLR4 in goose. Goose TLR4 encodes an 843-amino-acid protein, which contains a signal peptide, extracelluar leucine-rich repeat domain, a transmembrane region and a toll-interleukin-1 receptor signaling domain. The deduced goose TLR4 protein shows more than 70% identity to chicken and zebra finch, but less than 50% identity to its mammalian counterparts. Quantitative real-time analysis reveals that the goose TLR4 mRNA is more expressed in abdominal fat and liver. We also identify the changes of goose TLR4 mRNA expression pattern after over-feeding treatment, which may reveal that the expression of goose TLR4 could respond to over-feeding treatment.

Fang Wang, Lizhi Lu, Hao Yuan, Yong Tian, Jinjun Li, Junda Shen, Zhengrong Tao, and Yan Fu "cDNA cloning, characterization and expression analysis of toll-like receptor 4 gene in goose," Canadian Journal of Animal Science 91(3), 371-377, (1 September 2011). https://doi.org/10.1139/CJAS2011-002
Received: 7 January 2011; Accepted: 1 April 2011; Published: 1 September 2011
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KEYWORDS
Expression
Expression
over-feeding goose
Récepteur de type Toll 4 (TLR4)
suralimentation de l'oie
Toll-like receptor 4 (TLR4)
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