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17 March 2016 Single-nucleotide polymorphism of MC1R, ASIP, and TYRP2 genes in wild and farmed foxes (Vulpes vulpes)
Andrzej Jakubczak, Magdalena Gryzinska, Beata Horecka, Marek Kowalczyk, Kornel Kasperek, Katarzyna Gajewska, Grazyna Jezewska-Witkowska
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Abstract

DNA mutations within genes associated with melanogenesis can affect melanin production, leading to dyschromias. Genes that are involved in synthesis of melatonin and may affect the color of skin are melanocortin 1 receptor (MC1R), agouti locus (ASIP), and tyrosinase-related protein-2 (TYRP2). In this study, SNP identification within ASIP, MC1R, and TYRP2 gene fragments in wild and farmed foxes (Vulpes vulpes) was performed. Nine mutations in the ASIP gene which allowed us to distinguish seven SNP profiles, fourteen mutations and five SNP profiles in the MC1R gene, and seven SNP profiles based on four polymorphic nucleotides in the TYRP2 gene were detected. Analyses of obtained profiles indicate that ASIP did not undergo mutations in the wild, and significant variability of SNP profiles was found for TYRP2, with specific haplotypes noted for farm foxes and American and European wild foxes.

Copyright remains with the author(s) or their institution(s). This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
Andrzej Jakubczak, Magdalena Gryzinska, Beata Horecka, Marek Kowalczyk, Kornel Kasperek, Katarzyna Gajewska, and Grazyna Jezewska-Witkowska "Single-nucleotide polymorphism of MC1R, ASIP, and TYRP2 genes in wild and farmed foxes (Vulpes vulpes)," Canadian Journal of Animal Science 96(2), 172-179, (17 March 2016). https://doi.org/10.1139/cjas-2015-0066
Received: 7 April 2015; Accepted: 1 January 2016; Published: 17 March 2016
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