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30 August 2016 Effects of live yeast on immune responses and intestinal morphological structure in lipopolysaccharide-challenged broilers
Weiwei Wang, Wanli Ren, Zhui Li, Yunshuang Yue, Yuming Guo
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Abstract

The effects of live yeast (LY) on immune responses and intestinal morphological structure in lipopolysaccharide (LPS) challenged broilers were investigated. A total of 480 one-day-old male broilers were divided into six groups following a 3 × 2 factorial arrangement (eight replicates) with three dietary LY dosages (0%, 0.05%, or 0.50%) and two immune treatments (injection of saline or LPS) given at an interval of 48 h between 21 and 27 d of age. Blood was sampled on days 21 and 27, while intestine were collected on day 28. Results showed that LPS damaged (P ≤ 0.05) intestinal histomorphology, and tended to reduce (P=0.071) serum anti-Newcastle disease virus (NDV) titers on day 21, but increase (P=0.089) jejunal maltase activity. Supplemental LY at 0.05% elevated (P ≤ 0.05) ileal villus width and villus surface area, and serum anti-NDV titers on day 21. The addition at 0.50% increased (P ≤ 0.05) jejunal and ileal villus height to crypt depth ratio, reduced (P ≤ 0.05) jejunal maltase activity and crypt depth, and attenuated (P ≤ 0.05) LPS-induced increase (P ≤ 0.05) in serum diamine oxidase activity on day 21. Collectively, supplemental LY at 0.05% improved antibody response and the addition at 0.50% alleviated LPS-induced intestinal damage in broilers.

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Weiwei Wang, Wanli Ren, Zhui Li, Yunshuang Yue, and Yuming Guo "Effects of live yeast on immune responses and intestinal morphological structure in lipopolysaccharide-challenged broilers," Canadian Journal of Animal Science 97(1), 136-144, (30 August 2016). https://doi.org/10.1139/cjas-2015-0148
Received: 29 September 2015; Accepted: 1 August 2016; Published: 30 August 2016
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