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19 April 2018 Regulatory role of LEF-1 in the proliferation of Arbas White Cashmere goat dermal papilla cells
Fei Hao, Wei Yan, Xiaodong Guo, Bing Zhu, Dongjun Liu
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Abstract

Cashmere, which has high economic value, is made from the secondary hair follicles of cashmere goat skin. Dermal papilla cells (DPCs) are considered the center for regulation of hair growth, which is closely related to hair follicle growth. We constructed LEF-1 overexpression and interference experimental groups of goat DPCs to investigate LEF-1 regulation of DPCs proliferation by Wnt signaling, and provide a theoretical basis for improving cashmere yield. In primary DPCs, LEF-1, β-catenin, C-myc, and cyclin D1 expression in the LEF-1 overexpression group was 9.25-, 1.27-, 1.74-, and 1.63-fold, respectively, that of the control. LEF-1, β-catenin, C-myc, and cyclin D1 expression in the LEF-1 interference group was 0.20-, 0.75-, 0.38-, and 0.39-fold, respectively, that of the control. In secondary DPCs, LEF-1, β-catenin, C-myc, and cyclin D1 expression in the LEF-1 overexpression group was 10.53-, 1.48-, 1.64-, and 1.39-fold, respectively, that of the control. LEF-1, β-catenin, C-myc, and cyclin D1 expression in the LEF-1 interference group was 0.21-, 0.71-, 0.40-, and 0.36-fold, respectively, that of the control. Primary and secondary DPCs proliferation rates changed with LEF-1 expression. Therefore, the LEF-1 regulation pattern of cell proliferation through Wnt signaling is similar in both DPCs.

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Fei Hao, Wei Yan, Xiaodong Guo, Bing Zhu, and Dongjun Liu "Regulatory role of LEF-1 in the proliferation of Arbas White Cashmere goat dermal papilla cells," Canadian Journal of Animal Science 98(4), 667-674, (19 April 2018). https://doi.org/10.1139/cjas-2017-0130
Received: 21 August 2017; Accepted: 6 March 2018; Published: 19 April 2018
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KEYWORDS
cashmere goat
dermal papilla cell
LEF-1
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