Discussion is provided for an occurrence of Macbridea caroliniana thought to be extirpated (Berkeley County) and five new occurrences collected 2019–2020 on the South Carolina Coastal Plain. One new occurrence is a county record (Charleston County). Four new occurrences along the Black River through Berkeley and Williamsburg counties suggest favorable habitat in that region. Findings suggest that this species may be underreported in South Carolina and effort should be placed in identifying disturbed habitat in conserved natural areas that may harbor this rare plant.